Variation in VKORC1 Is Associated with Vascular Dementia
نویسندگان
چکیده
منابع مشابه
Uric acid is associated with vascular dementia in Chinese population
OBJECTIVE Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study w...
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متن کاملWhite matter damage is associated with matrix metalloproteinases in vascular dementia.
BACKGROUND AND PURPOSE Vascular disease causes multi-infarct dementia (MID) or Binswanger's disease (BD), the latter of which is a progressive form of vascular dementia (VaD) associated pathologically with fibrinoid and hyaline changes in brain arterioles with injury to the white matter. Clinically, BD patients have long-standing hypertension with disturbances of gait and intellect. Because mat...
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Any damage to the brain may affect cognition. However, although the effects of vascular changes have been known for years, involvement of such changes is becoming increasingly better recognized. In particular the effects of comorbid vascular disease to primary neurodegenerative processes adds to the complexity of the issue. An attempt to clarify the problems needed specific attention to differe...
متن کاملVKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
BACKGROUND The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on the formation of reduced-form vitamin K, a cofactor for gamma-carboxylation of vitamin K-dependent proteins, which is involved in the coagulation cascade and has a potential impact on atherosclerosis. We hypothesized that VKORC1-depende...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2021
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-201256